Evaluating Systems Pharmacology Models Is Different From Evaluating Standard Pharmacokinetic-Pharmacodynamic Models

نویسندگان

چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluating Systems Pharmacology Models Is Different From Evaluating Standard Pharmacokinetic–Pharmacodynamic Models

Based on the author's recent experience, there appears to be some confusion regarding the steps required to qualify a systems pharmacology model as adequate for the intended purpose. This manuscript outlines the model evaluation approach used in the author's recent publication(1) on the systems pharmacology of a 5-lipoxygenase inhibitor and is an attempt to generate discussion on this topic wit...

متن کامل

Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment

Simultaneous or sequential exposure to multiple chemicals may cause interactions in the pharmacokinetics (PK) and/or pharmacodynamics (PD) of the individual chemicals. Such interactions can cause modification of the internal or target dose/response of one chemical in the mixture by other chemical(s), resulting in a change in the toxicity from that predicted from the summation of the effects of ...

متن کامل

Evaluating Cigarette Demand Models

In the past 15 years there has been a substantial increase in the taxation of cigarettes in the United States. The federal government and most state governments have increased taxes on cigarettes in an effort to reduce smoking. In the period 1990-2003, the national average price of cigarettes increased by 85%. This paper will use data from 1990-2003 to examine the effect that these large price ...

متن کامل

Evaluating Density Forecasting Models

Density forecasting in regression is gaining popularity as real world applications demand an estimate of the level of uncertainty in predictions. In this paper we describe the two goals of density forecasting sharpness and calibration. We review the evaluation methods available to a density forecaster to assess each of these goals and we introduce a new evaluation method that allows modelers to...

متن کامل

Evaluating Student Models

We use the Additive Factors Model to drive the evaluation of the student model of an Intelligent Tutoring System. Using data from the Andes Physics Tutor, applying the simple location heuristic and implementing the Additive Factors Model tool in the Pittsburgh’s Science of Learning Center’s DataShop, we discover possible ways to improve the student model of the Andes Intelligent Tutor.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: CPT: Pharmacometrics & Systems Pharmacology

سال: 2014

ISSN: 2163-8306

DOI: 10.1038/psp.2013.77